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Samenvatting Exploring the structure and mechanics of aging soft tissues, this edited volume presents authoritative reviews from leading experts on a range of tissues including skin, tendons, vasculature and plantar soft tissues. It provides an overview of in vivo and in vitro measurement techniques including state-of-the-art methodologies, as well as focusing on the structural changes that occur within the main components of these tissues resulting in detrimental mechanical property changes. It also highlights the current challenges of this field, and offers an insight into future developments.

Age-related changes in the mechanical properties of soft tissues have a profound effect on human morbidity and mortality, and with changing global demographics, there is growing interest in this area. There has been increasing interest in robustly characterizing these mechanical changes to develop structure-property relationships, and growing awareness of the need for enhanced predictive models for computational simulations.

This book seeks to address the challenges involved in applying these engineering techniques to reliably characterize these tissues. Focusing on a wide range of tissues and presenting cutting-edge techniques, this book provides an invaluable reference to academics and researchers in a range of disciplines including biomechanics, materials science, tissue engineering, life sciences and biomedicine. Toon meer Toon minder. Reviews Schrijf een review. Bindwijze: Paperback.

The reinforced scaffolds are typically made of the gel-based systems reinforced with various fibers, including natural and synthetic materials, as summarized in Table 1. The main advantage of the reinforced composites is that they can capture the benefits of each material to overcome the limitations of each single-component scaffold. In addition, their another non-negligible advantages are that they can better mimic the microstructure and composition of natural soft tissues that are composed of collagen fibers embedded in a hydrogel-like matrix of elastin and meet the long-term functional requirements of biomechanics.

Over the past few years, the fiber-reinforced scaffold with their unique properties and functions play a key role in improving the biomechanics, biocompatibility, bioactivity, integration and degradation of artificial composite scaffolds in soft tissue repair and regeneration. In fact, fiber-based biomaterials with a wide range of morphological and mechanical properties have been widely used as reinforcing additives in soft tissue engineering to produce the desirable scaffold similar to ECM components in animal models and in clinical applications.

However, a series of new barriers in the research are emerged that researchers continue to overcome before successfully utilizing them in the in vitro research and clinical applications. Table 1. Examples of fiber-reinforced scaffolds in soft tissue engineering mentioned in the article. Despite the remarkable achievements of current research, there is still a need to develop advanced theories and satisfactory intensive processing techniques to achieve the fiber-reinforced scaffolds with favorable morphological structure, optical properties, electrical properties, biocompatibility, biochemical and biological properties, especially adequate mechanical properties.

Aiming at these goals, there are some important issues that we should focus on in the future. Firstly, With the development of materials engineering, life sciences and medicine, the next generation scaffold will be made of more intelligent and diverse materials, with a more satisfactory structure and function. Thus, an in-depth systematic study should be conducted on all the impact factors that affect the performance of the reinforced scaffold, such as the volume fraction, aspect ratio, direction and arrangement of the fiber. Secondly, the design of new composites depends to a large extent on its manufacturing technology and experimental conditions, which we should be concerned about.

Finally, the fiber-reinforced composites seeded with active enzymes, cells and antibodies are still a further study direction, which may make a difference on optimizing the next generation of engineered scaffolds for soft tissue repair. Oxford University Press is a department of the University of Oxford.

It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In. Advanced Search. Article Navigation. Close mobile search navigation Article Navigation. Volume 4. Article Contents. Fiber-reinforced scaffolds for cartilage tissue repair. Fiber-reinforced scaffolds for tendon and ligament repair. Fiber-reinforced scaffolds for vascular tissue repair. Fiber-reinforced scaffolds for skin tissue repair. Fiber-reinforced scaffolds for the intervertebral disc repair.

Fiber-reinforced scaffolds for corneal tissue repair. Fiber-reinforced scaffolds in soft tissue engineering Baoqing Pei. Oxford Academic. Google Scholar. Wei Wang. Yubo Fan. Xiumei Wang. Fumio Watari. Xiaoming Li. Cite Citation. Permissions Icon Permissions. Abstract Soft tissue engineering has been developed as a new strategy for repairing damaged or diseased soft tissues and organs to overcome the limitations of current therapies. Figure 1. Open in new tab Download slide.

Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. Biocomposites reinforced by fibers or tubes as scaffolds for tissue engineering or regenerative medicine. Search ADS. Electrospun ultrafine fibrous wheat glutenin scaffolds with three-dimensionally random organization and water stability for soft tissue engineering. Intrinsically water-stable electrospun three-dimensional ultrafine fibrous soy protein scaffolds for soft tissue engineering using adipose derived mesenchymal stem cells. Resin composites reinforced by nanoscaled fibers or tubes for dental regeneration.

Development of biodegradable polyurethane scaffolds using amino acid and dipeptide-based chain extenders for soft tissue engineering.

Three-dimensional electrospun ECM-based hybrid scaffolds for cardiovascular tissue engineering. Preparation and characterization of highly porous, biodegradable polyurethane scaffolds for soft tissue applications. Extracellular matrix as a bioactive material for soft tissue reconstruction. Effects of collagen membranes enriched with in vitro -differentiated N1E cells on rat sciatic nerve regeneration after end-to-end repair. Design and analysis of tissue engineering scaffolds that mimic soft tissue mechanical anisotropy. Determination of mechanical properties of soft tissue scaffolds by atomic force microscopy nanoindentation.

Investigating the morphological, mechanical and degradation properties of scaffolds comprising collagen, gelatin and elastin for use in soft tissue engineering. Elastase-sensitive elastomeric scaffolds with variable anisotropy for soft tissue engineering. Degradation and healing characteristics of small-diameter poly epsilon-caprolactone vascular grafts in the rat systemic arterial circulation. The regulation of phenotype of cultured tenocytes by microgrooved surface structure. A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering.

Collagen-Based substrates with tunable strength for soft tissue engineering. Collagen-based scaffolds reinforced by chitosan fibres for bone tissue engineering. In vitro cartilage tissue engineering with 3D porous aqueous-derived silk scaffolds and mesenchymal stem cells. Porous, resorbable, fiber-reinforced scaffolds tailored for articular cartilage repair.

Covalent attachment of a three-dimensionally printed thermoplast to a gelatin hydrogel for mechanically enhanced cartilage constructs. Silk microfiber-reinforced silk hydrogel composites for functional cartilage tissue repair. Enhanced mechanical properties of thermosensitive chitosan hydrogel by silk fibers for cartilage tissue engineering. Functional tissue engineering. Assessment of function in tendon and ligament repair. Current investigations into magnetic nanoparticles for biomedical applications.

Google Preview. Chronic rupture of tendo Achillis. Long-term results of operative management using polyester tape. Ipsilateral free semitendinosus tendon graft transfer for reconstruction of chronic tears of the Achilles tendon. Scaffolds for tendon and ligament repair: review of the efficacy of commercial products. Tissue engineering for anterior cruciate ligament reconstruction: a review of current strategies. Effect of fiber crosslinking on collagen-fiber reinforced collagen—chondroitinsulfate materials for regenerating load-bearing soft tissues.

A layered electrospun and woven surgical scaffold to enhance endogenous tendon repair. A novel electrospun-aligned nanoyarn-reinforced nanofibrous scaffold for tendon tissue engineering. The application of poly 3-hydroxybutyrate-cohydroxyhexanoate scaffolds for tendon repair in the rat model. Flavanols and anthocyanins in cardiovascular health: a review of current evidence. Mechanical behavior of a cellulose-reinforced scaffold in vascular tissue engineering. The use of microfiber composites of elastin-like protein matrix reinforced with synthetic collagen in the design of vascular grafts.


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Assembly of aligned polyvinyl alcohol—styrylpyridinium pendent group nanofibres for vascular tissue engineering applications. Nerve regeneration and elastin formation within poly glycerol sebacate -based synthetic arterial grafts one-year post-implantation in a rat model. Fast-degrading elastomer enables rapid remodeling of a cell-free synthetic graft into a neoartery. Skin tissue engineering— in vivo and in vitro applications.

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Electrospun synthetic human elastin. Defining the role of matrix compliance and proteolysis in Three-Dimensional cell spreading and remodeling. Improving the mechanical properties of chitosan-based heart valve scaffolds using chitosan fibers. Fiber-reinforced scaffolds for tissue engineering and regenerative medicine: use of traditional textile substrates to nanofibrous arrays.

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Woven silk fabric-reinforced silk nanofibrous scaffolds for regenerating load-bearing soft tissues. Tissue engineering of the intervertebral disc with cultured nucleus pulposus cells using atelocollagen scaffold and growth factors. Chemical and topographical effects on cell differentiation and matrix elasticity in a corneal stromal layer model.

Knox Cartwright. Improving the mechanical properties of collagen-based membranes using silk fibroin for corneal tissue engineering. Gelatin nanofiber-reinforced alginate gel scaffolds for corneal tissue engineering. A brief review of the modelling of the time dependent mechanical properties of tissue engineering scaffolds. Published by Oxford University Press. Issue Section:. Download all figures. View Metrics. Email alerts New issue alert. Advance article alerts.

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Mechanical properties of pelvic soft tissue of young women and impact of aging.

Nanoscale characterization of the biomechanical properties of collagen fibrils in the sclera vol , , Scanning acoustic microscopy of biological cryosections: the effect of local thickness on apparent acoustic wave speed Journal article Williams, C. Derby, B. Scanning acoustic microscopy of biological cryosections: the effect of local thickness on apparent acoustic wave speed.

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Rossignol, P. Cardiotrophin-1 is involved in cardiovascular and renal fibrosis and dysfunction Conference Paper Lopez-Andres, N.

Cardiotrophin-1 is involved in cardiovascular and renal fibrosis and dysfunction. Nanoindentation creep versus bulk compressive creep of dental resin-composites Journal article El-Saftya, S. Nanoindentation creep versus bulk compressive creep of dental resin-composites. Journal article El-Safty, S. Nanoindentation creep versus bulk compressive creep of dental resin-composites..

Dental materials : official publication of the Academy of Dental Materials, 28 11 , Nanomechanical properties of dental resin-composites Journal article El-Safty, S. Nanomechanical properties of dental resin-composites. Characterizing the elastic properties of tissues. Lattice strains and load partitioning in bovine trabecular bone Journal article Akhtar, R. Lattice strains and load partitioning in bovine trabecular bone. Localised micro-mechanical stiffening in the ageing aorta Journal article Graham, H. Localised micro-mechanical stiffening in the ageing aorta.

Conference Paper Zhao, X. In Materials Research Society symposia proceedings. Materials Research Society Vol. Quantifying micro-mechanical properties of soft biological tissues with scanning acoustic microscopy Conference Paper Zhao, X. Quantifying micro-mechanical properties of soft biological tissues with scanning acoustic microscopy. Fibrillin microfibrils as structural biomarkers of diabetes. Localising micro-mechanical stiffening in the ageing aorta Conference Paper Graham, H. Localising micro-mechanical stiffening in the ageing aorta. The effect of type 1 diabetes on the structure and function of fibrillin microfibrils Conference Paper Akhtar, R.

The effect of type 1 diabetes on the structure and function of fibrillin microfibrils. Journal article Akhtar, R. Materials Research Society symposia proceedings.

Mechanical Properties of Aging Soft Tissues by Brian Derby, Paperback | Barnes & Noble®

Materials Research Society, E Z , ukpmcpa Nanoindentation of histological specimens: Mapping the elastic properties of soft tissues Journal article Akhtar, R. Nanoindentation of histological specimens: Mapping the elastic properties of soft tissues. Effect of filler size and shape on local nanoindentation modulus of resin-composites. Elastic strains in antler trabecular bone determined by synchrotron X-ray diffraction Journal article Akhtar, R.

Elastic strains in antler trabecular bone determined by synchrotron X-ray diffraction. In-depth hardness profiles of Stainless Steel and Ni-Ti endodontic instrument cross-sections by nano-indentation Journal article Zinelis, S. In-depth hardness profiles of Stainless Steel and Ni-Ti endodontic instrument cross-sections by nano-indentation.

Load transfer in bovine plexiform bone determined by synchrotron x-ray diffraction Journal article Akhtar, R. Load transfer in bovine plexiform bone determined by synchrotron x-ray diffraction. Mapping the micromechanical properties of cryo-sectioned aortic tissue with Scanning Acoustic Microscopy. Mapping the micromechanical properties of cryo-sectioned aortic tissue with scanning acoustic microscopy Conference Paper Akhtar, R.