Guide The handbook of medicinal chemistry : principles and practice

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Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book will help readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to help medicinal chemists to apply their academic understanding to every aspect of drug discovery.

Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry.

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This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development. A free app has been created in collaboration with the editors of the book.

The Medicinal Chemistry Toolkit provides a suite of resources to support the day to day work of a medicinal chemist. Dr Davis has spent the last 23 years in drug discovery, in line management, project and portfolio management and senior science roles. He has a wide ranging experience of drug discovery in both large and small companies GlaxoSmithKline, Knoll Pharmaceuticals, Vernalis, Chiroscience and specialist experience of discovering and developing drugs for central nervous system indications. He has led multidisciplinary project teams and medicinal chemistry groups from target identification, through to early clinical studies, delivering multiple clinical development candidates across indications.

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Wermuth is co-author or editor of several books, the author of over scientific papers and holds nearly 60 patents. We are always looking for ways to improve customer experience on Elsevier. We would like to ask you for a moment of your time to fill in a short questionnaire, at the end of your visit. If you decide to participate, a new browser tab will open so you can complete the survey after you have completed your visit to this website.

Thanks in advance for your time. Skip to content. Search for books, journals or webpages All Pages Books Journals. View on ScienceDirect. Editors: Camille Wermuth Camille Wermuth. Hardcover ISBN: Imprint: Academic Press. Published Date: 24th July Page Count: Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle. When you read an eBook on VitalSource Bookshelf, enjoy such features as: Access online or offline, on mobile or desktop devices Bookmarks, highlights and notes sync across all your devices Smart study tools such as note sharing and subscription, review mode, and Microsoft OneNote integration Search and navigate content across your entire Bookshelf library Interactive notebook and read-aloud functionality Look up additional information online by highlighting a word or phrase.

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The Handbook Of Medicinal Chemistry: Principles And Practice

Drug discovery and the latest techniques NEW! Pharmaceutical researchers in drug discovery, chemists. A History of Drug Discovery I. Introduction II.

A text book of Medicinal Chemistry Principles of Medicinal Chemistry

Definitions and Objectives II. Drug Classification Systems References 3. Measurement and Expression of Drug Effects I. Ex Vivo Experiments IV. In Vivo Experiments References 4. Molecular Drug Targets I. G-Protein-Coupled Receptors X. Biopharmaceutical Therapies IV. Drug Target Identification V. Hit-to-Lead VI.

Clinical Biomarkers VII.

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Conclusion References 7. Historical Background III. From Screen to Lead IV. Conclusion References 8. Summary References 9. Biology Oriented Synthesis IV. Conclusion and Outlook References Data Mining Methods IV. Database Searches V. Applications VI. Conclusion and Future Directions References Fragment-Based Drug Discovery I.

The Practice of Medicinal Chemistry - 3rd Edition

What is FBDD? Nuclear Magnetic Resonance VI. X-ray Crystallography VII. Trends for the Future References Lead-Likeness and Drug-Likeness I. Conclusion References Blogs III. Wikis IV. Compound Information V.

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Biological Properties of Compounds VI.