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Inventory No: Name and address on end page otherwise unmarked-" Mr. Griffin marshals the evidence that cancer is a deficiency disease like scurvy or pellagra aggravated by the lack of an essential food compound in modem mans diet.

World Without Cancer: The Story of Vitamin B17

That substance is vitamin B In its purified form developed for cancer therapy, it is known as Laetrile. It is the most complete and authoritative treatise ever produced on Laetrile. Critics of Laetrile warn the public that eating apricot kernels is dangerous: They can make you sick and can even be fatal. The professional literature provides some evidence that negative effects can occur if you eat a lot of kernels at once, but unfortunately it tells us very little else. Laetrile proponents claim that about ten kernels per day 5 mg of cyanide is considered to be sufficient to prevent cancer and as many as 50 kernels is recommended to combat an existing cancer 25 mg of cyanide apricotseeds.

Are these doses dangerous?

Cancer Biology

I could find only two publications describing lethal consequences these two reports, however, are widely cited in anti-Laetrile publications. Sayre and Kaymakcalavu report that between and , two children died of cyanide poisoning in a hospital in Central Turkey after eating apricot kernels. No information was provided on how many kernels were consumed. Lasch and Shawa report two more deaths of children in Gaza. Once again, there was no information on how much was consumed. The case against against Laetrile rests on only two clinical studies.

The first actually provides some support for Laetrile but has been inaccurately cited Krashen, The second, a major study by the Mayo clinic, is considered definitive, but has lots of problems, including the use of terminal patients, a strong possibility that a much weaker kind of Laetrile was used a mix of pure and synthetic , the researchers' ignoring some signs of effectiveness, and an incorrect schedule in administering the Laetrile I have written a paper on this and have submitted it for publication.

I will be happy to send copies — write me at skrashen yahoo. Milazzo, Ernst, Lejeune, and Schmidt is a formal meta-analysis, that is, an attempt to quantity the impact of a treatment in many studies and report an overall effect.

World without cancer: The story of vitamin B17 | Blogs: BIOL – Spring

The results are simple to state: No studies met the methodological standards set by the researchers, that is, no studies in the literature examining the effect of Laetrile were randomized clinical trials. The authors concluded that "The claim that Laetrile has beneficial effects for cancer patients is not supported by data from controlled clinical studies. What the paper really showed was that there is no evidence one way or the other from controlled studies.

Serious Laetrile supporters do not claim it is a miracle cure-all; they claim that it is helpful and can sometimes provide a complete cure. The professional literature has a number of reports of patients who did well with Laetrile, reports written by professional physicians who report the cases carefully, and are not in the business of selling apricot pits. These cannot be ignored, and there are too many of them to attribute all to fraud, misdiagnoses or spontaneous remission. I hope a rational path can be followed with the use of Laetrile, a thorough investigation of its potential as a treatment for and preventative of cancer.

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Krashen, S. The Internet Journal of Alternative Medicine. Volume 6 Number 2. Does Laetrile work? Another look at the Mayo Clinic study Moertel et al. Submitted for publication. Lejeune, S. Laetrile treatment for cancer review. The Cochrane Library, Issue 3. Moss, R.

The Cancer Industry. Brooklyn: Equinox Press. June 13, 3. Oct 10, Cf. Edwards on Jan 26, "The data provided by the McNaughton Foundation certainly indicates some activity in animal tumour systems" emphasis added. Institute von ardenne Dresden, Germnay , H strain mice bearing Ehrlich ascites carcinoma treated with bitter almond amygdalin ad libitum in addition to regular chow diet, yielded increased life span and decreased rate of cancer growth, treatment beginning 15 days before cancer inoculation arch.

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No iota of activity, no shred of evidence? Source: The Arlin J. Tel: Immunopharmacol Immunotoxicol. The effect of amygdalin on cervical cancer cells has never been studied. In this study, we found that the viability of human cervical cancer HeLa cell line was significantly inhibited by amygdalin.

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The development of apoptosis in the amygdalin-treated HeLa cells were confirmed by double staining of amygdalin-treated HeLa cells with annexin V-FITC and propidium iodide PI along with increase in caspase-3 activity in these cells. Further studies indicated that antiapoptotic protein Bcl-2 was downregulated whereas proapoptotic Bax protein was upregulated in the amygdalin-treated HeLa cells implying involvement of the intrinsic pathway of apoptosis.

In vivo, amygdalin administration inhibited the growth of HeLa cell xenografts through a mechanism of apoptosis. The results in the present study suggest that amygdalin may offer a new therapeutic option for patients with cervical cancer.