Chemoprotective effect of the MD against breast cancer seemed to depend on individual's characteristics and potential risk factors, such as obesity, physical activity, smoking, age at menarche, and menopausal status. Diet and nutritional status are not only important factors in the etiology of breast cancer, but they are—major determinants of prognosis and treatment outcome in breast cancer patients.
Furthermore, scientific observations support the idea that dietary supplement can prevent breast cancer recurrences. Not limited only to breast cancer, malnutrition is frequently manifested in cancer patients, even at the time of diagnosis. In cancer patients, undernutrition may be due to various factors. Inflammation and catabolism created by the tumor can result in muscle wasting and weight loss, 48 whereas tumor gastrointestinal obstruction can impair food intake and absorption, as a result of dysphagia, pain, and vomiting.
In addition to this, the side effects of anticancer treatment, such as anorexia, nausea, vomiting, oral and intestinal mucositis with dysphagia, diarrhea, hemorrhoids, anal fissures, and modifications in smell and taste affect not only the total energy intake, but also the nutrient absorption, compromising nutritional status. Furthermore, the poor psychological state of cancer patients can affect their energy intake.
Substantial studies have shown that weight loss in cancer is associated with poor prognosis, poor quality of life, lower activity level, increased treatment-related adverse symptoms, and reduced tumor response to therapy. However, when patients stop losing weight they have better OS.
Socioeconomic development is usually associated with increasing wealth, changing lifestyle, and disease pattern leading to increase in life expectancy. This association of changes, known as epidemiological transition, is very well demonstrated in the Middle East, especially in the Gulf States, which have experienced rapid socioeconomic changes during the last four decades. As food habits trail changes in lifestyle, there has been a dramatic shift from the indigenous traditional healthy diet, which was based on whole wheat flour, fish, milk, and dates toward an affluent diet, which is rich in total calories, meat, saturated fat.
This change in dietary habits, taking place in parallel with reduced physical activity, may have contributed to the increase in the number of breast cancer cases in the regions. The findings reported in the literature are not conclusive enough to establish a pattern for the real cause of the disease. Globally there is sufficient evidence to strongly support the notion that overweight, obesity, and reduced physical activities have direct causal relationship to breast cancer.
Although very few studies are available to directly document such a relationship in the Arab world, circumstantial evidence clearly points to the possible role of the epidemic obesity in this population and the startling rise in cases of breast cancer. Well-designed and systematic studies are urgently needed to establish these associations.
Although this review has shown that dietary habits and lifestyle have an influence on the incidence of breast cancer, it is still evident that the main etiological factors are hormone related. McDonald et al. Strong and persistent efforts are also needed to promote an overall healthy lifestyle with special emphasis on diet that is rich in fruit and vegetables and whole grains and low in red meat and saturated fats. Continued and expanded research on diet, lifestyle and breast cancer risk is urgently needed to build the foundation for future progress in evidence-based public health efforts in this region of the world.
The authors are grateful to Ms. Dhuha Abdulla Naser for her assistance with the literature search. They acknowledge the funding of S. Conception and design: Z. No competing financial interests exist.
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Request Username Can't sign in? Forgot your username? Enter your email address below and we will send you your username. BioResearch Open Access Vol. Sakina E. References 1 Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52, women with breast cancer and , women without breast cancer.
Cancer magnitude, challenges and control in the Eastern Mediterranean region. East Mediterr Health J. Profile of cancer in the Eastern Mediterranean region: the need for action. Cancer Epidemiol. Cancer incidence in five continents. International Agency for Research on Cancer: Lyon, Association of reproductive factors with the incidence of breast cancer in Gulf Cooperation Council countries. Cancer epidemiology and control in the Arab world—past, present and future.
Asian Pac J Cancer Prev. Recent incidence and descriptive epidemiological survey of breast cancer in Saudi Arabia. Saudi Med J. Increasing prevalence of breast cancer among Saudi patients attending a tertiary referral hospital: a retrospective epidemiologic study. Croat Med J. Age at diagnosis of female breast cancer in Oman: issues and implications. South Asian J Cancer.
Pathobiological features of breast tumours in the State of Kuwait: a comprehensive analysis. J Carcinog.
Available at: www. Features of breast cancer in developing countries, examples from North-Africa. Eur J Cancer. Population attributable risk for breast cancer: diet, nutrition, and physical exercise. J Natl Cancer Inst. World cancer report. Google Scholar 15 World Health Organization. Cancer fact sheet N Prevalence and risk factors associated with nutrition-related noncommunicable diseases in the Eastern Mediterranean region.
Int J Gen Med. Nutrition-related health patterns in the Middle East. Asia Pac J Clin Nutr. The weight of nations: an estimation of adult human biomass. BMC Public Health. Global burden of cancer attributable to high body-mass index in a population-based study.
Lancet Oncol. World J Diabetes. Intake of dairy products, calcium, and vitamin D and risk of breast cancer. Dietary intake of vitamin D and calcium and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. Nutr Cancer. Vitamin D status and breast cancer in Saudi Arabian women: case-control study. Am J Clin Nutr. Dietary protein sources and incidence of breast cancer: a dose—response meta-analysis of prospective studies.
Adolescent meat intake and breast cancer risk. Int J Cancer. Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. Diet body size and breast cancer. Epidemiol Rev. Dietary factors and risk of breast cancer: combined analysis of 12 case-control studies. Frequency of meat and fish intake and risk of breast cancer in a prospective study of 14, Norwegian women. Dietary fat and fiber in relation to risk of breast cancer.
An 8-year follow-up. The search for the causes of breast and colon cancer. Dietary fat and breast cancer in Saudi Arabia: a case—control study. Alcohol as a risk factor for cancer: existing evidence in a global perspective. J Prev Med Public Health. Phytoestrogens and prevention of breast cancer: the contentious debate. World J Clin Oncol. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Marilie D. Charles Poole : Epidemiologic methods in cancer epidemiology. David B. Richardson : Studies of cancer among nuclear workers at several U.
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